A Simple Lattice Model That Captures Protein Folding, Aggregation and Amyloid Formation
نویسندگان
چکیده
منابع مشابه
A Simple Lattice Model That Captures Protein Folding, Aggregation and Amyloid Formation
The ability of many proteins to convert from their functional soluble state to amyloid fibrils can be attributed to inter-molecular beta strand formation. Such amyloid formation is associated with neurodegenerative disorders like Alzheimer's and Parkinson's. Molecular modelling can play a key role in providing insight into the factors that make proteins prone to fibril formation. However, fully...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2014
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0085185